Oct 23, 2026
San Diego, California Oct 22, 2026 (Issuewire.com) - Ting Therapeutics Advances TT004 into Phase Ib Clinical Trial as a Potential Chemoprotective Therapy for Cisplatin-Treated Patients
Ting Therapeutics, Inc., a biotechnology company developing therapies for treatment-related tissue injury, today announced that its lead candidate, TT004, has received IND approval in China and is advancing into Phase Ib clinical development as a potential chemoprotective therapy for patients receiving cisplatin chemotherapy.
Cisplatin is a highly effective cancer treatment, but its toxicities can substantially limit therapy. Approximately 40% of patients discontinue or modify chemotherapy because of treatment-related toxicities. Cisplatin can also cause permanent hearing loss in up to 80% of patients and acute kidney injury in approximately 30% of patients.
TT004 is designed to protect normal tissues from cisplatin toxicity while preserving its anticancer activity. In preclinical studies, TT004 increased survival following cisplatin exposure three-fold and reduced cisplatin-induced hearing loss and kidney injury by approximately 70%, without compromising cisplatin's anticancer effects.
"These findings support our vision of TT004 as a chemoprotective therapy that could improve the tolerability of cisplatin while maintaining its anticancer efficacy," said Jian Zuo, PhD, Co-Founder and CEO of Ting Therapeutics. "Our goal is to reduce the suffering caused by cisplatin treatment-related toxicities, help more patients receive and complete effective chemotherapy, and improve their long-term quality of life."
Ting Therapeutics recently licensed its China rights for TT004 to Rising Dragon, a Chinese biotechnology company, for development in China. The companies jointly developed TT004 as an oral tablet and obtained IND approval from China's Center for Drug Evaluation (CDE) for first-in-human clinical evaluation.
The Phase Ib trial, conducted in collaboration with oncologists and otolaryngologists at Eye and ENT Hospital of Fudan University in Shanghai, will evaluate the safety and tolerability of oral TT004 administered with standard-of-care cisplatin chemotherapy in patients with head and neck cancer. The study has received institutional ethics approval and is preparing to initiate patient recruitment.
TT004's protective effects have been demonstrated only in preclinical models and have not yet been shown in humans. This trial is the first clinical evaluation of TT004 and an important step toward determining whether these effects can be translated to cancer patients.
About Ting Therapeutics
Founded in 2018, Ting Therapeutics, Inc. develops novel and repurposed therapeutics to prevent and treat hearing loss and other treatment-related tissue injuries. The Company's pipeline targets hearing loss associated with chemotherapy, noise exposure, antibiotics, aging, and other causes.
Contact:
Jian Zuo, PhD, Co-Founder & CEO
Ting Therapeutics, Inc.
6868 Nancy Ridge Dr., San Diego, CA 92121
[email protected]
Source :Ting Therapeutics, Inc.
This article was originally published by IssueWire. Read the original article here.
Jacaranda trees are turning parks and streets purple across Sydney, sparking a frenzied rush of photographers and weddings.
Fresh Hong Kong graduates are increasingly feeling the impact of artificial intelligence (AI) as they enter the workforce, human resources experts have said, after a survey found the starting salaries for degree holders and sub-degree graduates had narrowed. The results of the latest annual survey by Baptist University found the disparity between the starting salaries of bachelor’s degree and sub-degree graduates narrowed by 17 per cent, or HK$500 (US$63.70), from HK$3,000 last year to HK$2,500...
The Australian sharemarket has opened lower after AI stocks tumbled on Wall Street, while oil prices hit their highest levels since May on worries about the war with Iran.
A Killara man was arrested after his home was raided by heavily armed tactical police on Thursday.
Kelly’s Law has passed parliament which will disqualify the licences of people facing dangerous driving charges.
A possible tornado whipped through a San Clemente golf course Wednesday, leaving behind a trail of tree carcasses.
Los Angeles County prosecutors will not file criminal charges against a man who punched a self-described "MAGA influencer" earlier this year. David Vulin, who was out with his infant son and husband in West Hollywood, reacted after the streamer suggested gay men were likely to molest their children.
The Asia Society announced on Thursday that it had marked out territory on the Washington policy landscape with the purchase of a US$17.5 million building that will give it a permanent spot alongside other US capital think tanks dating back more than a century, striving for influence. The 70-year-old institution, founded by the grandson of oil mogul John D. Rockefeller, has focused more on public policy in recent years, in addition to its traditional focus on arts, culture and education, under...
The world’s first major trial of a personalised therapeutic cancer vaccine has been hailed a ‘foundational shift’ in how we research and treat cancer.
Heavily armed tactical police swarmed the property on Thursday morning.
For Tanoé Akouba Leïla Olivia, modeling was the last thing on her mind when she came to Korea, because she was certain about her aspirations of working as an architect. Her professional training in interior design and 3D visualization in the U.K., Italy and Spain cemented her commitment to the field, until a career break in Korea made her rethink her path and eventually become a full-time model. Born in Cote d’Ivoire to an Ivorian father and Malian mother, Leïla spent her early childhood traveling between countries due to the nature of her parents’ work. Her childhood was filled with memories of the bright streets of Manchester, the antique avenues of Spain and the bustling roads of Italy. From time to time, she would find herself enjoying the flavorful food in Nigeria and exploring the historical and colorful streets of Togo and Senegal. This lifestyle led her to consider herself “un enfant du monde” — a French expression meaning “child of the world.” After completing her internship in Marbella and Valencia, she took a big leap and moved to China to work as a 3D visua
Of the roughly 70,000 adults reported missing in Korea every year, nearly all are found within weeks. But a small fraction vanish without a trace, and some stay missing for decades. According to data from the National Police Agency submitted in August to Rep. Chung Choon-saeng of the Rebuilding Korea Party, the share of missing adult cases resolved within 30 days has stayed near 99 percent over the past five years. It stood at 98.8 percent in 2022, 98.9 percent in 2023, 98.8 percent in 2024, 99 percent in 2025 and 99.4 percent through July 2026. For the slim remainder, however, investigators run out of leads. Here are some of Korea’s most baffling adult missing person cases that remain unsolved. Veterinary student Lee Yun-hee (2006) Lee Yun-hee, a veterinary student at Jeonbuk National University in Jeonju, North Jeolla Province, went missing 20 years ago and has never been found. On June 5, 2006, she attended an end-of-semester gathering with professors and classmates at a restaurant roughly 1.5 kilometers from her studio apartment. She returned home around 2:30 a.m. the next day. Lee
YOUR NEWS, OUR NETWORK.
Do you have Great News you want to tell the world?
Be it updates about your business or your community, you can make sure that it’s heard by submitting your story to our network reaching hundreds of news sites across 6 verticals.